Gene information
Official symbol ABCB1
Official full name ATP binding cassette subfamily B member 1
Gene type protein-coding gene
Chromosome7q21.12
Alias symbolP-gp; CD243; GP170; ABC20
Previous symbolPGY1; MDR1; CLCS
Gene familyCD molecules; ATP binding cassette subfamily B
Resources
Entrez Gene 5243
HGNC HGNC:40
Ensembl ENSG00000085563
Vega OTTHUMG00000023393
UCSC uc003uiz.3
GO terms: 52 records
GO Description Category LogP Number of genes Detail
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0005319 lipid transporter activity GO Molecular Functions -5.47143795 11 More
GO:0005342 organic acid transmembrane transporter activity GO Molecular Functions -1.32561631 5 More
GO:0005548 phospholipid transporter activity GO Molecular Functions -2.19985109 4 More
GO:0006869 lipid transport GO Biological Processes -16.6388990 29 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008525 phosphatidylcholine transporter activity GO Molecular Functions -3.00303064 3 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009636 response to toxic substance GO Biological Processes -18.1818984 46 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010232 vascular transport GO Biological Processes -6.06441304 9 More
GO:0010876 lipid localization GO Biological Processes -20.1994935 34 More
GO:0015399 primary active transmembrane transporter activity GO Molecular Functions -1.80269149 6 More
GO:0015748 organophosphate ester transport GO Biological Processes -5.98331847 11 More
GO:0015849 organic acid transport GO Biological Processes -6.14345140 15 More
GO:0015914 phospholipid transport GO Biological Processes -7.60367088 11 More
GO:0016324 apical plasma membrane GO Cellular Components -4.50542891 15 More
GO:0022804 active transmembrane transporter activity GO Molecular Functions -1.58321714 10 More
GO:0022898 regulation of transmembrane transporter activity GO Biological Processes -11.1988499 41 More
GO:0031625 ubiquitin protein ligase binding GO Molecular Functions -1.82192201 21 More
GO:0032409 regulation of transporter activity GO Biological Processes -16.9480646 53 More
GO:0032411 positive regulation of transporter activity GO Biological Processes -5.68668981 10 More
GO:0032412 regulation of ion transmembrane transporter activity GO Biological Processes -9.90560995 38 More
GO:0032414 positive regulation of ion transmembrane transporter activity GO Biological Processes -4.25838891 8 More
GO:0034204 lipid translocation GO Biological Processes -2.41427787 4 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0034767 positive regulation of ion transmembrane transport GO Biological Processes -11.2867591 18 More
GO:0042626 ATPase-coupled transmembrane transporter activity GO Molecular Functions -2.20105170 5 More
GO:0042886 amide transport GO Biological Processes -5.62242821 10 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0044070 regulation of anion transport GO Biological Processes -12.6410846 24 More
GO:0045177 apical part of cell GO Cellular Components -8.17813885 46 More
GO:0046943 carboxylic acid transmembrane transporter activity GO Molecular Functions -1.33493457 5 More
GO:0047484 regulation of response to osmotic stress GO Biological Processes -3.72261873 5 More
GO:0090554 phosphatidylcholine floppase activity GO Molecular Functions -4.05291246 3 More
GO:0097035 regulation of membrane lipid distribution GO Biological Processes -2.19985109 4 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098754 detoxification GO Biological Processes -12.4136065 17 More
GO:0140115 export across plasma membrane GO Biological Processes -3.24021630 5 More
GO:0140303 intramembrane lipid transporter activity GO Molecular Functions -1.89871863 3 More
GO:0140326 ATPase-coupled intramembrane lipid transporter activity GO Molecular Functions -2.40746524 3 More
GO:0140328 floppase activity GO Molecular Functions -3.08353391 3 More
GO:0140352 export from cell GO Biological Processes -8.94733589 48 More
GO:0140359 ABC-type transporter activity GO Molecular Functions -3.54822320 5 More
GO:0150104 transport across blood-brain barrier GO Biological Processes -6.06441304 9 More
GO:1903793 positive regulation of anion transport GO Biological Processes -7.11509809 13 More
GO:1903959 regulation of anion transmembrane transport GO Biological Processes -6.29956701 6 More
GO:1903961 positive regulation of anion transmembrane transport GO Biological Processes -3.59511628 3 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa02010 ABC transporters KEGG Pathway -3.72474182 5 More
hsa04976 Bile secretion KEGG Pathway -3.16953788 6 More
hsa05226 Gastric cancer KEGG Pathway -5.33653529 20 More
Drug-Gene interaction
view
Related drugs: 240 records
Drug name Interaction type Source PMID View
2',4'-dihydroxychalcone DTC 22112540 view
2'-hydroxychalcone DTC 22112540 view
3,4-dihydroxyxanthone DTC view
7-ethyl-10-hydroxycamptothecin PharmGKB view
acenocoumarol PharmGKB 24919870 view
adriamycin NCI 136388511069027 view
agomelatine PharmGKB view
aldosterone PharmGKB view
aliskiren PharmGKB view
amiodarone PharmGKB view
amisulpride PharmGKB 29443543 view
amitriptyline PharmGKB 24192121182156182670473922641028 view
amprenavir PharmGKB view
anastrozole PharmGKB view
aripiprazole PharmGKB 29443543 view
astemizole PharmGKB view
atazanavir NCI 16355344 view
atenolol PharmGKB view
atorvastatin NCIPharmGKB 16103896213927221561615026932749198028231923864918851956 view
austocystin d DTC 21348461 view
bafetinib CIViC 18191450 view
bepridil PharmGKB view
biricodar PharmGKBTTD view
bisantrene NCI 9816258 view
bleomycin PharmGKB 25637052 view
boceprevir PharmGKB 25836019 view
brecanavir DTC 17664327 view
bromocriptine NCI 118564859514944 view
bromperidol PharmGKB view
camptothecin NCI 9918583 view
capecitabine PharmGKB 2114291522026922 view
capsaicin NCI 16674925 view
carboplatin NCI 11157479 view
carvedilol PharmGKB view
celiprolol PharmGKB view
ceritinib CIViC 26870817 view
chembl203365 DTC 16271474 view
chembl217425 DTC 18257545 view
chembl270688 DTC 18257545 view
chembl306786 DTC 16271474 view
chembl408422 DTC 18311899 view
chembl410907 DTC 18311899 view
chembl444075 DTC 26197160 view
chembl533293 DTC view
chembl595816 DTC 22112540 view
chlorpromazine NCIPharmGKB 16810505 view
cimetidine PharmGKB view
cisplatin PharmGKB 2993834422016816237461842133231420530282 view
citalopram PharmGKB 2419212118215618267047392264102821546862 view
clarithromycin NCIPharmGKB 16221754 view
clomipramine PharmGKB 21449676 view
clopidogrel PharmGKB 2636247324262617247628602813576317112805218314102891434425060201283780582080149827380588255428071910608325850030237260912336477522045970230562882294000521806387245354872835884228589365254300462065043521918510231501512939756820801494227239592219006322028352222853002299006722624833 view
clozapine PharmGKB 271681011959316822722500 view
codeine DTCPharmGKB 1831189922398969 view
colchicine TENDPharmGKB 25876828 view
crizotinib CIViC 26870817 view
curcumin NCIPharmGKB 15090070 view
cyanocobalamin PharmGKB view
cyclosporine DTCNCIPharmGKB 21348461247204521796417023922006197276111754602183349151844494524088131230178882180638625536375249921531720663525240575261077541857690312966368187179152003068022886152 view
cytarabine PharmGKB 25558979209384652556721716331627 view
dabigatran PharmGKB 2789318227261537 view
daptomycin PharmGKB 25239468 view
daunorubicin NCIPharmGKB 2555897920938465255672171050077716331627 view
deferoxamine NCI 12514119 view
delavirdine DTC 21189339 view
dendroamide a DTC 8786364 view
desipramine PharmGKB view
dexamethasone PharmGKB 2917795418408561 view
dexrazoxane PharmGKB 25558979209384652556721716331627 view
dextromethorphan NCI 15582917 view
dicloxacillin PharmGKB 1577842218576903 view
digoxin NCI 1596993116674925 view
dihydro-12-hydroxy-2,2-dimethyl-2h,6h-pyrano[3,2-b]xanthen-6-one DTC view
diltiazem PharmGKB view
dipyridamole PharmGKB view
disulfiram PharmGKB view
docetaxel PharmGKB 21151855 view
domperidone NCIPharmGKB 15285840 view
doxorubicin NCIPharmGKB 29938344220168161140851125637052183774302558257518408561 view
doxycycline NCIPharmGKB 11850258 view
dronabinol NCI 16439618 view
e-flupentixol PharmGKB view
efavirenz DTCPharmGKB 206626242449799731628422125451402704542520860463118091842677452323734829207205172062535221189339162677642530329416912956 view
elacridar PharmGKB 17932689 view
epirubicin NCI 15161039 view
epothilone d DTC 24992153 view
erlotinib PharmGKB view
erythromycin PharmGKB view
etoposide PharmGKB 12969965 view
etravirine DTC 21189339 view
everolimus PharmGKB view
felodipine PharmGKB view
fenofibrate NCI 16316932 view
fentanyl PharmGKB 29601950222776782788332317192767119645991951413023557865 view
fexofenadine PharmGKB 11503014 view
filgrastim NCI 7564516 view
flavokawain a DTC 22112540 view
fluorouracil NCI 16892554 view
fluoxetine PharmGKB 241921211821561824663076 view
fluphenazine PharmGKB view
fluvastatin PharmGKB 16002074 view
fluvoxamine PharmGKB 182156182670473922641028 view
gabapentin NCI 17328248 view
garlic NCI 11466175 view
gefitinib NCIPharmGKB 25554506166514352708993715155841 view
gemtuzumab ozogamicin NCI 11986941 view
granisetron PharmGKB 2917757027241063 view
haloperidol PharmGKB view
heterocodeine DTC 18311899 view
hydrocortisone NCIPharmGKB 16873536 view
hydroxocobalamin PharmGKB view
ibuprofen NCI 11583291 view
idarubicin PharmGKB 25558979209384652556721716331627 view
imatinib NCI 1580525215155841 view
indinavir PharmGKB view
irinotecan PharmGKB 27845419 view
isoniazid PharmGKB 196864642216299229036176 view
itraconazole NCIPharmGKB 15969931 view
ivermectin PharmGKB view
ketoconazole PharmGKB view
lamivudine PharmGKB 23996099 view
lamotrigine PharmGKB view
lansoprazole PharmGKB 17190370 view
lenalidomide PharmGKB 29177954 view
levetiracetam PharmGKB view
levofloxacin PharmGKB view
lithium PharmGKB 21449676 view
lonafarnib NCI 14671431 view
loperamide PharmGKB view
lopinavir DTCPharmGKB 1766432723996099 view
losartan PharmGKB 27338075 view
lovastatin NCIPharmGKB 1561615010213372 view
maprotiline PharmGKB view
mefloquine PharmGKB view
melphalan PharmGKB view
methadone NCI 15876424 view
methylphenidate PharmGKB 23771192 view
methylprednisolone PharmGKB 14583680 view
metochalcone DTC 22112540 view
miconazole NCI 15969931 view
midazolam PharmGKB view
mifepristone PharmGKB view
miltefosine NCI 11355955 view
miltirone DTC 26339922 view
mitomycin PharmGKB view
mitoxantrone PharmGKB view
modafinil PharmGKB 26757307 view
morphine DTCPharmGKB 2470309225311385183118991658090029474345251559321951413017898703 view
murucoidin v DTC 22148475 view
nefazodone PharmGKB 21449676 view
nelfinavir DTCPharmGKB 20662624176643272086046311809184237348291626776416912956 view
nevirapine DTCPharmGKB 20017669211893391691295716912956 view
nicardipine PharmGKB view
nicotine NCI 16191663 view
nifedipine NCI 10213372 view
nimodipine NCI 14743973 view
nitrendipine PharmGKB view
nortriptyline PharmGKB 12082591 view
olanzapine PharmGKB 180864752944354317038883 view
omeprazole PharmGKB 1597698929377228 view
ondansetron PharmGKB 2501272620707787 view
oxcarbazepine PharmGKB 28837897 view
oxycodone PharmGKB 2120923419514130 view
paclitaxel DTCNCICIViC 162896361587642416467099 view
pantoprazole PharmGKB 15976989 view
paroxetine PharmGKB 2419212118215618214496762670473922641028 view
pentazocine PharmGKB view
pervilleine b DTC 11754602 view
pervilleine c DTC 11754602 view
pervilleine d DTC 11754602 view
pervilleine f DTC 11754602 view
phenobarbital NCIPharmGKB 1692844925846690 view
phenothiazine NCI 16750172 view
pravastatin NCIPharmGKB 1966711015616150 view
prednisolone PharmGKB 1458368025582575 view
prednisone PharmGKB 1217573125637052 view
probenecid NCI 9182837 view
progesterone PharmGKB view
propafenone PharmGKB view
propofol PharmGKB 29755652 view
propranolol NCIPharmGKB 15023456 view
purgin ii DTC 23273047 view
quercetin-3'-o-phosphate TdgClinicalTrial view
quinidine NCIPharmGKB 1671173 view
quinine PharmGKB view
ranitidine NCIPharmGKB 9862768 view
ranolazine PharmGKB 24433361 view
remifentanil PharmGKB 29755652 view
reserpine DTCPharmGKB 2327304722148475 view
rifampin PharmGKB view
risperidone PharmGKB 297239282458990926129906294435431999708023609392 view
ritonavir DTCPharmGKB 17324111261747191460057417664327249973171635534423996099287185151655344212888252515120720504240256220641714896626857335 view
rituximab NCIPharmGKB 2563705216971809 view
rivaroxaban PharmGKB 27893182 view
rocuronium PharmGKB 25279974 view
rucaparib PharmGKB view
saquinavir PharmGKB view
scutellarin DTC 22822035 view
sertraline PharmGKB 24192121182156182670473922641028 view
sevoflurane PharmGKB view
silibinin PharmGKB 26595166 view
simeprevir PharmGKB view
simvastatin NCIPharmGKB 15616150198028231632162119891551 view
sirolimus NCIPharmGKB 230734672867693314569063 view
sorafenib PharmGKB view
sparfloxacin PharmGKB view
spironolactone NCIPharmGKB 16740618 view
sufentanil PharmGKB view
sunitinib PharmGKB 2577846527564227248749292624457424013576 view
talinolol PharmGKB 22725663 view
tamoxifen PharmGKB view
tangeretin DTC view
tariquidar inhibitor DTCTdgClinicalTrialChemblInteractionsPharmGKB 21657271 view
taxol c DTC 16289636 view
temozolomide PharmGKB 31624332 view
temsirolimus PharmGKB 28676933 view
teniposide PharmGKB view
terfenadine NCIPharmGKB 114547241021337216842392 view
tesmilifene inducer TdgClinicalTrial 1641368110755318 view
tetrabenazine PharmGKB view
tetracycline PharmGKB view
tipifarnib PharmGKB 15122075 view
topotecan PharmGKB view
trabectedin PharmGKB 24024892 view
trimetrexate NCI 10360822 view
valganciclovir PharmGKB 27402191 view
valinomycin PharmGKB view
valspodar PharmGKB view
vecuronium PharmGKB view
vemurafenib PharmGKB 23116250 view
venlafaxine PharmGKB 24192121182156182144967626704739267573072264102826664259 view
verapamil DTCNCI 2460799922405646213484611796417098627682220948625686592117546022242950924992153236838341825754521856049203636351671173 view
vinblastine DTC 2134846120363635 view
vincristine PharmGKB 2993834422016816256370522558257518408561 view
vindesine PharmGKB 25637052 view
voacamine inhibitor DTC 162732162472045214612920 view
voriconazole PharmGKB 19033450 view
warfarin PharmGKB 25312789298756682224828629432897 view
zidovudine NCIPharmGKB 229606622399609915456083 view
zosuquidar inhibitor TdgClinicalTrialPharmGKB 18157518 view
Related studies: 3 records
Molecular factor Omics type Application Objective MI type Reference
NC_000007.14:g.[87509329A>T;87509216A>C;87515500G>C;87501081C>T] genomics hemorrhage[prognosis (bad)] ST elevation myocardial infarction Zhang JH et al. Thromb Res. 2014
NM_000927.5:c.3085-72C>T genomics hemorrhage[prognosis (bad)] ST elevation myocardial infarction Zhang JH et al. Thromb Res. 2014
NM_000927.5:c.3435T>C genomics hemorrhage[prognosis (bad)] ST elevation myocardial infarction Zhang JH et al. Thromb Res. 2014
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